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Direct evidence that functionally impaired CD4+ T cells persist in vivo following induction of peripheral tolerance.
Pape, K A; Merica, R; Mondino, A; Khoruts, A; Jenkins, M K.
Afiliação
  • Pape KA; Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis 55455, USA.
J Immunol ; 160(10): 4719-29, 1998 May 15.
Article em En | MEDLINE | ID: mdl-9590217
A small population of CD4+ OVA-specific TCR transgenic T cells was tracked following the induction of peripheral tolerance by soluble Ag to address whether functionally unresponsive, or anergic T cells, persist in vivo for extended periods of time. Although injection of OVA peptide in the absence of adjuvant caused a transient expansion and deletion of the Ag-specific T cells, a population that showed signs of prior activation persisted in the lymphoid tissues for several months. These surviving OVA-specific T cells had long-lasting, but reversible defects in their ability to proliferate in lymph nodes and secrete IL-2 and TNF-alpha in vivo following an antigenic challenge. These defects were not associated with the production of Th2-type cytokines or the capacity to suppress the clonal expansion of a bystander population of T cells present in the same lymph nodes. Therefore, our results provide direct evidence that a long-lived population of functionally impaired Ag-specific CD4+ T cells is generated in vivo after exposure to soluble Ag.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Tolerância Imunológica Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Tolerância Imunológica Limite: Animals Idioma: En Revista: J Immunol Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Estados Unidos País de publicação: Estados Unidos