Childhood-onset porphyria cutanea tarda: successful therapy with low-dose hydroxychloroquine (Plaquenil).
J Am Acad Dermatol
; 38(5 Pt 2): 810-4, 1998 May.
Article
em En
| MEDLINE
| ID: mdl-9591792
ABSTRACT
We describe a 4-year-old girl with a spontaneous blistering disorder that was consistent with porphyria cutanea tarda (PCT). There was no familial history of the disease or any obvious causative factors present. Oral hydroxychloroquine (3 mg/kg) was given twice weekly along with vitamin E (200 U/d) as an antioxidant. Within 6 weeks, marked decreased blistering occurred and by 12 weeks no blistering was evident. Despite clinical improvement and tolerance of hydroxychloroquine, urinary uroporphyrin, aspartate aminotransferase, and ferritin levels continued to rise reaching peak levels at 16 weeks of therapy. Near total biochemical remission was observed at 40 weeks and all therapy was discontinued at 60 weeks.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Porfiria Cutânea Tardia
/
Antirreumáticos
/
Hidroxicloroquina
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Child, preschool
/
Female
/
Humans
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos