Endothelin-1 enhances nitric oxide-induced cell death in cultured vascular smooth-muscle cells.
J Cardiovasc Pharmacol
; 31 Suppl 1: S351-3, 1998.
Article
em En
| MEDLINE
| ID: mdl-9595479
ABSTRACT
Increased expression of endothelin-1 (ET-1) immunoreactivity is demonstrated in the active atherosclerotic plaque. Here we show that both ETA and ETB receptors are expressed in rat vascular smooth-muscle cells (VSMCs). ET-1 binding to ETB receptors enhances nitric oxide-induced cell death in VSMCs. These findings suggest that ET-1 may participate in the mechanism of cell death (apoptosis) in the plaque through activation of ETB-mediated pathways and that a selective ETB receptor antagonist could be useful in preventing acute plaque alterations, such as plaque rupture.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Endotelina-1
/
Músculo Liso Vascular
/
Óxido Nítrico
Limite:
Animals
Idioma:
En
Revista:
J Cardiovasc Pharmacol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Japão