An approach to understanding the mechanisms of poliovirus persistence in infected cells of neural or non-neural origin.
Clin Diagn Virol
; 9(2-3): 107-13, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9645992
ABSTRACT
BACKGROUND:
Poliovirus (PV) is the etiologic agent of paralytic poliomyelitis, which is sometimes followed, after decades of clinical stability, by new symptoms, including progressive muscular atrophy, collectively known as the post-polio syndrome. This raises the question of possible PV persistence in post polio patients.OBJECTIVE:
To test the capacity of PV to establish persistent infections in human cells, three models were developed. STUDYDESIGN:
This review focuses on the viral and cellular parameters involved in persistent PV infection.RESULTS:
Many PV strains, which are generally lytic in primate cell lines, are able to establish persistent infections in human neuroblastoma cells. During persistent infection, PV mutants (PVpi) are consistently selected, and several of their capsid substitutions occur at positions known to be involved in PV-PV receptor interactions. PVpi have a particular property they can establish persistent infections in non-neural HEp-2 cells. PV can also persistently infect primary cultures of human fetal brain cells and the majority of cells which survive infection belong to the neuronal lineage.CONCLUSIONS:
The results obtained with the three models of persistent PV infection in human cells suggest that several mechanisms are used by PV to establish and maintain persistent infections in neural and non-neural cells. The interactions of the virus with its receptor seem to be a key-step in all cases. In the future, the elucidation of the etiology of the post-polio syndrome will require the characterization of PV sequences having persisted for decades in post-polio patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Latência Viral
/
Poliovirus
/
Neurônios
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Clin Diagn Virol
Assunto da revista:
VIROLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França