IgG binding sites on human Fc gamma receptors.
Int Rev Immunol
; 16(1-2): 57-85, 1997.
Article
em En
| MEDLINE
| ID: mdl-9651786
ABSTRACT
The structure for the three human Fc gamma receptors classes Fc gamma RI (CD64), Fc gamma RII (CD32) and Fc gamma RIII (CD16) has been well characterized. Here the IgG binding sites on Fc gamma RII and Fc gamma RII with their responsive FG, BC and C'/E loops on the membrane proximal domains are described in detail. For Fc gamma RI the second extracellular domain is suggested as a key structure of IgG binding. The lower hinge regions of human and murine IgG binding to these Fc receptors and their structural relationship in Fc gamma R-IgG interactions are discussed. The potential of inhibiting the pathophysiological effects of Fc gamma receptors by blocking studies are considered for future therapeutic modalities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sítios de Ligação de Anticorpos
/
Imunoglobulina G
/
Receptores de IgG
Limite:
Humans
Idioma:
En
Revista:
Int Rev Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
1997
Tipo de documento:
Article