Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients.
FASEB J
; 12(10): 855-62, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9657525
ABSTRACT
Cyclic AMP-dependent protein kinase A (PKA) type I has been established as an acute inhibitor of T cell activation. For this reason, we investigated the possible role of PKA type I in HIV-induced T cell dysfunction. T cells from HIV-infected patients have increased levels of cAMP and are more sensitive to inhibition by cAMP analog than are normal T cells. A PKA type I-selective antagonist increases the impaired proliferation of T cells from HIV-infected patients to normal or subnormal levels (up to 2.8-fold). Follow-up of patients after initiation of highly active antiretroviral treatment revealed that a majority of patients have a persistent T cell dysfunction that is normalized by incubation of T cells with Rp-8-Br-cAMPS. These observations imply that increased activation of PKA type I may contribute to the progressive T cell dysfunction in HIV infection and that PKA type I may be a potential target for immunomodulating therapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Proteínas de Transporte
/
Infecções por HIV
/
Proteínas Quinases Dependentes de AMP Cíclico
/
Fármacos Anti-HIV
/
Peptídeos e Proteínas de Sinalização Intracelular
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
FASEB J
Assunto da revista:
BIOLOGIA
/
FISIOLOGIA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Noruega