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Subclinical peripheral nerve involvement in patients with rheumatoid arthritis.
Lanzillo, B; Pappone, N; Crisci, C; di Girolamo, C; Massini, R; Caruso, G.
Afiliação
  • Lanzillo B; Fondazione Salvatore Maugeri, Campoli, Italy.
Arthritis Rheum ; 41(7): 1196-202, 1998 Jul.
Article em En | MEDLINE | ID: mdl-9663475
OBJECTIVE: Clinical involvement of the peripheral nervous system is uncommon in rheumatoid arthritis (RA); the most common disorders are multiple mononeuritis, sensorimotor neuropathy, and entrapment neuropathy. This study was undertaken to investigate the occurrence of electrophysiologically evident peripheral nerve involvement in RA patients without a clinical history of peripheral nerve involvement. METHODS: Forty RA patients were examined neurologically and electrophysiologically, and sural nerve biopsies were performed in 4. RESULTS: No patient reported symptoms or signs of peripheral nerve involvement. Twenty-six patients (65%) exhibited electrophysiologic findings consistent with a sensorimotor neuropathy (in 2 of them a carpal tunnel syndrome was also present), while 3 patients showed isolated carpal tunnel syndrome. There was a moderate loss of myelinated fibers in 3 of the 4 nerve biopsy samples, and all showed an increased number of endo- and perineurial vessels and some signs of axonal degeneration. CONCLUSION: Patients with RA may have electrophysiologic and histologic findings of peripheral nerve damage, even in the absence of clinical evidence of peripheral nerve involvement.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nervos Periféricos / Artrite Reumatoide Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Rheum Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Itália País de publicação: Estados Unidos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nervos Periféricos / Artrite Reumatoide Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Arthritis Rheum Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Itália País de publicação: Estados Unidos