Non-Hodgkin's lymphomas and myeloid disorders: deletions associated with t(2;5) and t(3;5) detected by FISH.
Leukemia
; 12(7): 1159-62, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9665204
ABSTRACT
The nucleophosmin (NPM) gene is involved in two recurrent translocations in hematological malignancies t(2;5) (p23;q35) in anaplastic large cell lymphoma (ALCL) and t(3;5)(q25.1;q34-35) in myelodysplasia and acute non-lymphocytic leukemia (ANLL). Using eight YACs encompassing the 5q34-q35 region, we could easily detect these two translocations. In both types of translocation, probable unexpected deletions were also discovered downstream of the breakpoint at 5q35.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
/
Síndromes Mielodisplásicas
/
Leucemia Mieloide Aguda
/
Linfoma Difuso de Grandes Células B
/
Deleção de Genes
Tipo de estudo:
Risk_factors_studies
Limite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Leukemia
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França