Model to study long-term effects of propoxyphene napsylate (darvon-N) on narcotic-dependent mice.
Res Commun Chem Pathol Pharmacol
; 15(1): 75-88, 1976 Sep.
Article
em En
| MEDLINE
| ID: mdl-9676
ABSTRACT
Five different strains of mice were investigated for their suitability to serve as models for the study of long-term effects of propoxyphene napsylate (PN) on narcotic-dependent mice. The NIH/Swiss outbred strain proved to be most suitable because of its high liability to manifest physical dependence on morphine. Following removal of subcutaneously-implanted morphine pellets from the mice, the incidence of spontaneous withdrawal jumping was used as a quantifiable criterion of physical dependence. An orally administered suspension of PN suppressed the withdrawal jumping in a dose-dependent manner. However, chronic (daily) administration of PN at doses high enough to prevent withdrawal jumping was characterized by a high degree of toxicity.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dextropropoxifeno
/
Dependência de Morfina
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Res Commun Chem Pathol Pharmacol
Ano de publicação:
1976
Tipo de documento:
Article