Gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols from Piper gibbilimbum.
J Nat Prod
; 61(7): 939-41, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9677279
ABSTRACT
Fractionation of the petroleum ether extract from the leaves of Piper gibbilimbum collected in Papua New Guinea afforded four new alkenylphenols, gibbilimbols A-D (1-4). The structures of the isolates were elucidated by spectroscopic methods, mainly 1D- and 2D-NMR spectroscopy. Gibbilimbols A-D were found to be toxic to brine shrimp with an LC50 of approximately 5 microg/mL. Gibbilimbols A-D were further found to be cytotoxic toward KB nasopharyngal carcinoma cells (ED50 7.8-2.1 microg/mL). All isolates also showed antibacterial activity toward Staphylococcus epidermidis and Bacillus cereus.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenóis
/
Plantas Medicinais
/
Folhas de Planta
/
Antibacterianos
/
Antineoplásicos Fitogênicos
Limite:
Humans
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
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