Effect of hyperlipidaemic diet and clofibrate treatment on rat erythrocyte lipids.
Scand J Haematol
; 17(2): 117-22, 1976 Aug.
Article
em En
| MEDLINE
| ID: mdl-968444
ABSTRACT
Lipids of rat plasma and erythrocytes were analysed during hyperlipidaemic diet and clofibrate treatment. The diet increased the plasma cholesterol and phospholipid concentrations after 3 weeks' lipid feeding. Clofibrate in a dose of 200 mg/kg body weight did not inhibit the increase in plasma cholesterol and phospholipid contents, but significantly decreased the concentration of plasma triglycerides. The lipid diet slightly increased the erythrocyte cholesterol and phospholipid concentrations without affecting the red cell morphology or reticulocytosis. After 1 week's treatment, clofibrate in a dose of 200 mg/kg body weight caused a 2-fold increase in the cholesterol content and a rise in the cholesterol-phospholipid ratio of red blood cells of rats fed the hyperlipidaemic diet. These results suggest that the erythrocyte cell membrane can increase its cholesterol content and possibly play a role in cholesterol transport.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Gorduras na Dieta
/
Clofibrato
/
Eritrócitos
/
Lipídeos
Limite:
Animals
Idioma:
En
Revista:
Scand J Haematol
Ano de publicação:
1976
Tipo de documento:
Article