[Diagnostic molecular biology in breast cancer]. / Diagnostisk molekylaerbiologi ved brystkreft.
Tidsskr Nor Laegeforen
; 118(15): 2366-9, 1998 Jun 10.
Article
em Nor
| MEDLINE
| ID: mdl-9691806
ABSTRACT
Studies of molecular genetic changes in breast carcinoma are slowly improving our understanding of the biological process which leads to a normal breast epithelial cell becoming a carcinoma cell with invasive and metastatic properties. Carriers of germ-line mutations in the breast cancer susceptibility genes BRCA1 and BRCA2 are particularly prone to develop breast cancer. Genetic screening and counselling programs have been established to identify individuals at high risk and provide intervention to reduce the suffering and mortality associated with breast cancer. In the future, the identification of specific molecular genetic changes in tumours may be applied as diagnostic and prognostic tools. An improved understanding of the molecular genetic mechanisms underlying the development of breast cancer may eventually yield novel therapeutic strategies, attacking specific genetic changes in the tumour.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Biomarcadores Tumorais
/
Genes BRCA1
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
Nor
Revista:
Tidsskr Nor Laegeforen
Ano de publicação:
1998
Tipo de documento:
Article