[Pathogenesis of androgen insensitivity syndrome].
Nihon Rinsho
; 56(7): 1881-6, 1998 Jul.
Article
em Ja
| MEDLINE
| ID: mdl-9702070
ABSTRACT
Androgen plays an important role in male sexual differentiation and the defect of androgen action mainly due to androgen receptor abnormality causes androgen insensitivity syndrome (AIS). The number of the reports of AR gene mutations is AIS reaches more than 250, including structural mutations such as gene deletion and single base mutations. The intriguing characteristics of the single amino acid substitutions by single base mutations are that they tend to occur in restricted areas and on restricted bases, and that the same mutation sometimes shows phenotypic variation even among the family members. In addition, in some AIS cases, neither androgen binding abnormality nor AR gene mutation is detected. In these cases, other factors which take part in transcriptional activation by AR might be affected.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Síndrome de Resistência a Andrógenos
/
Receptores Androgênicos
Tipo de estudo:
Etiology_studies
Limite:
Female
/
Humans
/
Male
Idioma:
Ja
Revista:
Nihon Rinsho
Ano de publicação:
1998
Tipo de documento:
Article