Synthesis and conformational analysis of a novel type of spin labelled bicyclonucleoside based on a tetrahydrofurano[2,3-c]pyrrolidine sugar skeleton.
Nucleosides Nucleotides
; 17(6): 1019-31, 1998 Jun.
Article
em En
| MEDLINE
| ID: mdl-9708321
ABSTRACT
Bicyclonucleosides bearing a 5-deoxy-5-N-hydroxyamino-3,N5-(1,1-ethano)-beta-D-furanosyl sugar moiety (15-18) have been prepared by glycosidation of the corresponding bicyclosugars obtained via an intramolecular reverse Cope elimination. The configuration of the asymmetric carbon of the 1,1-ethano bridge is the most important factor directing the conformation of the N-hydroxypyrrolidine ring and its invertomers ratio as shown by variable temperature H NMR experiments.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Timina
/
Uridina
/
Furanos
Idioma:
En
Revista:
Nucleosides Nucleotides
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Suíça