Bcl-2 family expression in salivary glands from patients with primary Sjögren's syndrome: involvement of Bax in salivary gland destruction.
Clin Immunol Immunopathol
; 88(2): 133-41, 1998 Aug.
Article
em En
| MEDLINE
| ID: mdl-9714690
ABSTRACT
To investigate the molecular mechanism of glandular parenchyma destruction in Sjögren's syndrome (SS), Bcl-2, Bax, Bcl-X, and Bak expression were studied. SS (n = 18) and control salivary glands (n = 6) were examined by immunohistochemistry. Apoptosis was assessed by in situ DNA nick end labeling. Infiltrating mononuclear cells in the SS salivary gland showed elevated Bcl-2. These mononuclear cells expressed increased Bax but did not undergo apoptosis. Both SS and control salivary gland ductal epithelial cells expressed Bcl-2, Bax, and Bcl-X. SS, but not normal, salivary gland acinar cells expressed Bax and underwent apoptosis. These results suggest that elevated Bax expression in SS salivary gland acinar cells may play an important role in the apoptotic pathway. In contrast, Bcl-2 expression in SS infiltrating mononuclear cells and ductal cells may contribute to their survival.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândulas Salivares
/
Síndrome de Sjogren
/
Proteínas Proto-Oncogênicas c-bcl-2
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Clin Immunol Immunopathol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos