Prognostic markers in bladder cancer: a contemporary review of the literature.
J Urol
; 160(3 Pt 1): 645-59, 1998 Sep.
Article
em En
| MEDLINE
| ID: mdl-9720515
ABSTRACT
PURPOSE:
We provide a contemporary review of bladder tumor markers and summarize their role as prognostic indicators. MATERIALS ANDMETHODS:
A comprehensive review of the literature on prognostic markers for transitional cell carcinoma of the bladder was performed.RESULTS:
Intense research efforts are being made to identify and characterize better various bladder cancers and their true biological potential. The need to predict which superficial tumors will recur or progress and which invasive tumors will metastasize has led to the identification of a variety of potential prognostic markers. Blood group antigens, tumor associated antigens, proliferating antigens, oncogenes, peptide growth factors and their receptors, cell adhesion molecules, tumor angiogenesis and angiogenesis inhibitors, and cell cycle regulatory proteins have recently been identified. The potential clinical applications of these tumor markers are under active investigation. Recent attention has focused on which tumor markers may predict the responsiveness of a particular bladder cancer to systemic chemotherapy.CONCLUSIONS:
At present conventional histopathological evaluation of bladder cancer (tumor grade and stage) cannot predict accurately the behavior of most bladder tumors. With a better understanding of the cell cycle, and cell to cell and cell to extracellular matrix interactions as well as improved diagnostic techniques (immunohistochemistry), progress is being made to identify and characterize other potential prognostic markers for transitional cell carcinoma of the bladder. The ultimate goal is to develop reliable prognostic markers that will accurately predict not only the course but also the response of a tumor to therapy. This information may then be used to dictate more aggressive treatment for tumors that are likely to progress and less aggressive treatment for those that are unlikely to progress. In the future these biological markers may also be used in gene therapy for the treatment of bladder cancer.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Bexiga Urinária
/
Carcinoma de Células de Transição
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
J Urol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos