Direct evidence that LTC4 and LTB4 but not TXA2 are involved in asthma attacks in children.
J Asthma
; 35(5): 445-8, 1998.
Article
em En
| MEDLINE
| ID: mdl-9734352
ABSTRACT
There are substantial numbers of reports showing that leukotrienes (LTs) play important roles in adult asthma. No definite evidence has been demonstrated that LTs are involved in asthma attacks in children, although it is highly expected. In this report, we demonstrated that the levels of LTB4 and LTC4 but not thromboxane B2 (TXB2), a stable metabolite of TXA2, were significantly elevated in the bronchoalveolar lavage fluid, which was obtained from intubated and mechanically ventilated children with severe asthma attacks. This is direct evidence that LTB4 and LTC4 predominantly participate in asthma attacks in pediatric patients.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Asma
/
Tromboxano A2
/
Leucotrieno C4
/
Leucotrieno B4
Limite:
Adolescent
/
Child, preschool
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Asthma
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Japão