[Results of 10 years of a randomized trial of neoadjuvant chemotherapy in breast cancers larger than 3 cm]. / Résultats à 10 ans d'un essai randomisé de chimiothérapie néo-adjuvante dans les cancers du sein de plus de 3 cm.
Chirurgie
; 123(3): 247-56, 1998 Jun.
Article
em Fr
| MEDLINE
| ID: mdl-9752515
ABSTRACT
AIM OF THE STUDY The aim of this randomised trial was to determine advantages and drawbacks of neo-adjuvant chemotherapy in patients with operable breast cancers > 3 cm. MATERIAL AND METHODS:
Two hundred and seventy-two women (age 70) with operable breast cancers larger than 3 cm (T2-3/N0-1/M0) were included in a randomised trial from January 1, 1985 to April 30, 1989. Patients in group A (n = 138) were treated by mastectomy and axillary node dissection. Adjuvant chemotherapy was indicated for 104 patients with axillary node involvement (n = 82) or negative oestrogen and progesterone receptors (EPR-) (n = 22). Patients in group B (n = 134) were treated by initial chemotherapy (identical as in group A) followed by locoregional treatment according to the response. Before treatment, the average of clinical tumoural diameter was 43 mm.RESULTS:
The median follow-up was 124 months. In group B, 49 patients (36.5%) were resistant to chemotherapy; a conservative breast surgical treatment was performed in the other 84 patients sensitive to chemotherapy (62.6%). In this last subgroup, 19 (22.6%) needed a secondary mastectomy because of locoregional recurrence. Survival rates were not different in groups A and B, but loco-regional recurrences were frequent in group B. At 10 years, the overall survival rate was 60% and half of living patients in group B were free of cancer and with their breast.CONCLUSION:
Neoadjuvant chemotherapy permitted in two-thirds of cases breast conservation treatment, initially considered to be impossible. Locoregional recurrences are more frequent than after mastectomy and adjuvant chemotherapy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Protocolos de Quimioterapia Combinada Antineoplásica
Tipo de estudo:
Clinical_trials
Limite:
Aged
/
Female
/
Humans
Idioma:
Fr
Revista:
Chirurgie
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
França
País de publicação:
FR
/
FRANCE
/
FRANCIA
/
FRANÇA