Central nervous system depressant activities of melatonin in rats and mice.
Indian J Exp Biol
; 36(3): 257-63, 1998 Mar.
Article
em En
| MEDLINE
| ID: mdl-9754058
ABSTRACT
Melatonin (10 and 20 mg/kg) potentiated pentobarbitone (45 mg/kg) induced hypnosis; it (50 and 100 mg/kg) decreased both total and ambulatory activity; produced (10, 25 and 50 mg/kg) hypothermia and possessed (10-400 mg/kg) significant analgesic property both in tail-flick and acetic acid-induced writhing tests. Melatonin in low dose (10 mg/kg) significantly reduced the forced-swimming induced immobility period per se and also reserpine induced immobility. While the antinociceptive effect of melatonin was sensitive to reversal by naloxone (2 mg/kg), other CNS depressant profile resembled the effects of benzodiazepines.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Depressores do Sistema Nervoso Central
/
Melatonina
Limite:
Animals
Idioma:
En
Revista:
Indian J Exp Biol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Índia