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Electrophysiological and neuropharmacological study of tectoreticular pathways in lampreys.
Zompa, I C; Dubuc, R.
Afiliação
  • Zompa IC; Centre de Recherche en Sciences Neurologiques, Université de Montréal, Montréal, Québec, Canada.
Brain Res ; 804(2): 238-52, 1998 Sep 07.
Article em En | MEDLINE | ID: mdl-9757053
ABSTRACT
Tectoreticular (TR) cells along the diencephalic-mesencephalic border are the origin of prominent crossed and uncrossed pathways that project to the middle (MRRN) and posterior (PRRN) rhombencephalic reticular nuclei in juvenile and adult lampreys [I.C. Zompa, R. Dubuc, Diencephalic and mesencephalic projections to rhombencephalic reticular nuclei in lampreys, Brain Res. (1998) in press.]. This study investigated the synaptic contacts between TR axons and the reticular cells. Intracellular recordings were carried out in reticular neurones (n=124) while microstimulating the TR regions. Tectoreticular inputs were recorded in all reticular cells studied (248 PSPs); although stronger responses were evoked in the MRRN neurones. The majority of responses were excitatory, but increasingly mixed and inhibitory when recorded in the middle and caudal part of the reticular nuclei. The excitation had the shortest onset latencies and sharpest slopes measured in both reticular nuclei, while the inhibition was longer and smoother. The characteristics of TR inputs to different reticular cell types is also presented. The transmission of evoked responses was isolated to the crossed and uncrossed TR pathways by studying the effects of 1% Xylocaine ejections and surgical lesions. The TR inputs were transmitted to reticular cells through monosynaptic and polysynaptic contacts. The synaptic transmission involved excitatory amino acids, acting through AMPA and NMDA receptors, while the inhibition was glycinergic. Comparisons with other sensory systems in lampreys are discussed.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Formação Reticular / Rombencéfalo / Lampreias Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Canadá
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Formação Reticular / Rombencéfalo / Lampreias Limite: Animals Idioma: En Revista: Brain Res Ano de publicação: 1998 Tipo de documento: Article País de afiliação: Canadá