K-ras mutations in stools and tissue samples from patients with malignant and nonmalignant pancreatic diseases.
Clin Chem
; 44(10): 2103-7, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9761241
ABSTRACT
Mutant-enriched PCR and reverse dot blot hybridization in microplates were applied for examining K-ras status in stools and tissue samples from patients with pancreatic tumors and chronic pancreatitis. In tissue samples, K-ras mutations were found in 32 of 35 cases of ductal adenocarcinoma, in 5 of 7 periampullary cancers, in 1 cystadenocarcinoma, and in 3 of 5 patients with chronic pancreatitis. In stools, mutated K-ras was seen in 10 of 25 cases of ductal adenocarcinoma, in 1 case of cystadenocarcinoma, and in 2 of 6 cases of chronic pancreatitis. These data indicate that the K-ras status of stool samples may help identify pancreatic carcinoma and persons at risk for cancer development; however, it does not allow discrimination of malignant from nonmalignant diseases.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pâncreas
/
Ductos Pancreáticos
/
Neoplasias Pancreáticas
/
Pancreatite
/
Adenocarcinoma
/
Proteína Oncogênica p21(ras)
/
Mutação Puntual
/
Fezes
Limite:
Humans
Idioma:
En
Revista:
Clin Chem
Assunto da revista:
QUIMICA CLINICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Alemanha