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Age-related differences in the secretion of calcitonin in female rats.
Lu, C C; Tsai, S C; Wang, S W; Huang, W J; Wang, P S.
Afiliação
  • Lu CC; Department of Physiology, School of Life Science, National Yang-Ming University, Taipei, Republic of China.
Am J Physiol ; 275(5): E735-9, 1998 11.
Article em En | MEDLINE | ID: mdl-9814990
The mechanism that causes hypercalcitonemia in female rats and is associated with aging was investigated. Young (3 mo), adult (8 mo), middle-aged (12 mo), and old (21 mo) rats were infused with CaCl2 and were bled from a jugular catheter after a CaCl2 challenge. To mimic some of the hormonal changes caused by aging, the anterior pituitary (AP)-grafted ovariectomized rats with hyperprolactinemic syndrome were used to mimic the physiological status of aging. The rat thyroid gland was incubated with or without ovine prolactin (oPRL; 40 or 80 ng/ml) at 37 degreesC for 30 min. Old rats possessed the lowest levels of plasma estradiol and progesterone yet had the highest levels of plasma prolactin and calcitonin (CT) compared with young, adult, and middle-aged rats. The basal release of thyroid CT in vitro in thyroid glands gradually increased with age. Compared with cortex (CX)-grafted rats, the AP-grafted rats possessed higher levels of plasma PRL, basal and CaCl2-induced levels of plasma CT, and the release of thyroid CT in thyroid glands. After stimulation with oPRL, the in vitro release of thyroid CT increased in both CX- and AP-grafted rats. These results suggest that the hypersecretion of CT in old rats is due at least in part to hyperprolactinemia.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adeno-Hipófise / Prolactina / Glândula Tireoide / Envelhecimento / Calcitonina Limite: Animals Idioma: En Revista: Am J Physiol Ano de publicação: 1998 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Adeno-Hipófise / Prolactina / Glândula Tireoide / Envelhecimento / Calcitonina Limite: Animals Idioma: En Revista: Am J Physiol Ano de publicação: 1998 Tipo de documento: Article País de afiliação: China País de publicação: Estados Unidos