Mechanistically diverse enzyme superfamilies: the importance of chemistry in the evolution of catalysis.
Curr Opin Chem Biol
; 2(5): 607-12, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9818186
The strategy that nature has used to evolve new catalytic activities from pre-existing enzymes (i.e. retention of substrate binding or of catalytic mechanism) has been controversial. Recent work supports a strategy in which a partial reaction, catalyzed by a progenitor, is retained, and the active-site architecture is modified to allow the intermediate generated to be directed to different products.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fosfopiruvato Hidratase
/
Proteínas de Bactérias
/
Catálise
/
Enoil-CoA Hidratase
/
Evolução Biológica
/
Amidoidrolases
Idioma:
En
Revista:
Curr Opin Chem Biol
Assunto da revista:
BIOQUIMICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos
País de publicação:
Reino Unido