Progressive and persistent downregulation of surface CXCR4 in CD4(+) T cells infected with human herpesvirus 7.
Blood
; 92(12): 4521-8, 1998 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-9845516
ABSTRACT
We have previously shown that infection of CD4(+) T lymphocytes with the T-lymphotropic human herpesvirus 7 (HHV-7) downregulates surface CD4, which represents the high-affinity receptor for HHV-7. In this study, we report that HHV-7 infection also causes a progressive loss of the surface CXC-chemokine receptor 4 (CXCR4) in CD4(+) T cells, accompanied by a reduced intracellular Ca2+ flux and chemotaxis in response to stromal cell-derived factor-1 (SDF-1), the specific CXCR4 ligand. Moreover, CXCR4 is downregulated from the surface of HHV-7-infected T cells independently of CD4. Because intracellular CXCR4 antigen and mRNA levels are unaffected in productively HHV-7-infected cells, the downregulation of CXCR4 apparently does not involve a transcritional block. Since CXCR4 functions in association with CD4 to permit entry of several human immunodeficiency virus (HIV) isolates, the potential of HHV-7 to persistently downregulate the surface expression of CXCR4 may provide novel strategies for limiting HIV infection.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T CD4-Positivos
/
Regulação para Baixo
/
Herpesvirus Humano 7
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Infecções por Herpesviridae
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Receptores CXCR4
Limite:
Humans
Idioma:
En
Revista:
Blood
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Itália