Standardization of acellular pertussis vaccine by assay of serum neutralizing antibodies to pertussis toxin (antitoxin): analogy with diphtheria toxoid.
Dev Biol Stand
; 95: 155-8, 1998.
Article
em En
| MEDLINE
| ID: mdl-9855426
ABSTRACT
Immunity conferred by vaccination with cellular pertussis vaccines and pertussis wanes so that adults are now the main reservoir of B. pertussis. Similar to diphtheria toxoid, acellular pertussis vaccines are suitable for vaccination of adults and it is probable that addition of pertussis toxoid to DT will be recommended for this age group. If this can be achieved, it is easy to predict that pertussis will be eliminated and the possibility of eradicating B. pertussis will become feasible. We propose that, despite the relative inaccuracy of correlating levels of antitoxin with individual immunity, a standardized assay and reference antiserum for pertussis toxoid will control acellular pertussis vaccines as was achieved with diphtheria toxoid.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacina contra Coqueluche
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Animals
/
Humans
Idioma:
En
Revista:
Dev Biol Stand
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos