Comparison of an anti-HSV-2 monoclonal IgG and its IgA switch variant for topical immunoprotection of the mouse vagina.
J Reprod Immunol
; 40(1): 93-101, 1998 Oct.
Article
em En
| MEDLINE
| ID: mdl-9862259
ABSTRACT
An IgG2a monoclonal antibody (Mab) directed against glycoprotein D of herpes simplex virus 2 (HSV-2) was compared with an IgA heavy chain Mab switch variant to investigate the effect of isotype for topical immunoprotection of the murine vagina. The IgA Mab, a mixture of monomeric and polymeric IgA, was indistinguishable from its IgG parent in an in vitro HSV-2 neutralization assay. When these class switched Mabs were delivered to the mouse vagina, we also found no significant difference between the IgG and IgA for preventing vaginal transmission of HSV-2 infection. The implications of these results for active and passive immunization strategies against vaginal transmission of genital herpes infections are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina A
/
Imunoglobulina G
/
Herpes Genital
/
Switching de Imunoglobulina
/
Herpesvirus Humano 2
/
Anticorpos Monoclonais
/
Anticorpos Antivirais
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
J Reprod Immunol
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos