The design, synthesis, and structure-activity relationships of a series of macrocyclic MMP inhibitors.
Bioorg Med Chem Lett
; 8(16): 2087-92, 1998 Aug 18.
Article
em En
| MEDLINE
| ID: mdl-9873491
ABSTRACT
A series of succinate-derived hydroxamic acids incorporating a macrocyclic ring were designed, synthesized, and evaluated as inhibitors of matrix metalloproteinases. The inhibitors were designed based on the published X-ray crystal structure of batimastat (1) complexed with human neutrophil collagenase (MMP-8). The synthesized compounds were shown to inhibit selected MMPs in vitro with low nanomolar potency.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fenilalanina
/
Inibidores de Proteases
/
Tiofenos
/
Colagenases
/
Inibidores de Metaloproteinases de Matriz
/
Ácidos Hidroxâmicos
Limite:
Humans
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Estados Unidos