Selective and reversible reduction of odor sensitivity in the rat by concanavalin A.
Physiol Behav
; 65(3): 513-6, 1998 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-9877418
ABSTRACT
Rats were trained using an olfactometer to detect low concentrations of ethyl acetate (EA) or dimethyl disulphide vapor (DMDS). Concanavalin A (ConA) applied to the olfactory mucosa had no effect on ability of rats to detect low concentrations of EA but produced a marked deficit in detection in DMDS. DMDS detection performance returned to control levels 3 days after the ConA treatment. These results provide the first behavioral evidence for odor-specific inhibition by chemical modification of the olfactory epithelium and support the notion that ConA selectively inactivates one or more types (subclasses) of olfactory receptor proteins.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Olfato
/
Concanavalina A
/
Odorantes
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
Physiol Behav
Ano de publicação:
1998
Tipo de documento:
Article
País de afiliação:
Alemanha