[Changes of kappa/lambda ratio of human serum immunoglobulins in the course of development]. / Veränderungen des kappa/lambda-Verhältnisses der menschlichen Serumimmunglobuline im Verlaufe der Entwicklung

ABSTRACT

In sera of normal individuals of different age groups the kappa- and lambda-type immunoglobulins were measured and the kappa/lambda ratio was calculated. The relative concentration of lambda-immunoglobulins in sera of newborns and young children was found to be significantly higher than in the adult sera. The well-known asynchronous maturation of immunoglobulin classes and IgG subclasses in the early childhood is evidently accompagnied by a asynchronous maturation of immunoglobulin types.