Vaccination with live Escherichia coli expressing Brucella abortus Cu/Zn superoxide dismutase protects mice against virulent B. abortus.
Infect Immun
; 67(2): 986-8, 1999 Feb.
Article
em En
| MEDLINE
| ID: mdl-9916121
ABSTRACT
Vaccination of mice with Escherichia coli expressing Brucella Cu/Zn superoxide dismutase (SOD) [E. coli(pBSSOD)] induced a significant level of protection against virulent Brucella abortus challenge, although this level was not as high as the one reached with B. abortus vaccine strain RB51. In addition, vaccination with E. coli(pBSSOD) induced antibodies to Cu/Zn SOD and a strong proliferative response of splenocytes when stimulated in vitro with a thioredoxin-Cu/Zn SOD fusion protein.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Superóxido Dismutase
/
Brucella abortus
/
Brucelose
/
Vacinas Bacterianas
/
Vacinas Sintéticas
Limite:
Animals
Idioma:
En
Revista:
Infect Immun
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Chile