Apoptosis of Th1-like cells in experimental tuberculosis (TB).
Clin Exp Immunol
; 115(2): 324-8, 1999 Feb.
Article
em En
| MEDLINE
| ID: mdl-9933460
ABSTRACT
Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-gamma) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Apoptose
/
Células Th1
/
Imunidade Celular
Limite:
Animals
Idioma:
En
Revista:
Clin Exp Immunol
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Índia