Clinical aspects of defective luteal phase and its treatment with cyclofenil. Syn: bis-(p-acetoxyphenyl) cyclohexylidenemethane (compound F 6066)

ABSTRACT

Fifty patients with variable duration of infertility due to defective luteal phase have been studied during a total of 446 menstrual cycles. Variables of atypical basal body temperature in such patients have been analysed, and correlated between various abnormal temperature pattern in defective luteal phase on the one hand, and hormonal and endometrial histology on the other have been defined. While it is stressed that atypical basal body temperature is only a gross indicator of the abnormal corpus luteal function, the various abnormal basal body temperature can provide useful information of defective follicular maturation and functions. Cyclofenil, a Cycloalkylidine derivative, has been found to be a relatively effective drug in correcting the complex hormonal behaviour in these patients leading to successful pregnancy outcome. The success of such an encouraging result depended on the strength of the drug used, and also on the gonadotrophin make-up of individual patients, viz., endogenous oestrogen level, signifying an intact and inter-dependent hypothalmico pituitary axis on the one hand and gonad capable enough to respond to stimulation from the pituitary control on the other. The endometrial sensitivity and its maturation is the ultimate result depending largely for its response on such a plan (AU)