Concurrent multicentric angiofollicular lymph node hyperplasia and peripheral T-cell lymphoma

ABSTRACT

Multicentric angiofollicular lymph node hyperplasia (MAFH) is a variant of Castleman's disease, localized angiofollicular lymph node hyperplasia. Unlike Castleman's disease, MAFH sometimes runs an aggressive clinical course culminating in death, mainly from infection and rarely from malignant lymphoma. The lymphoma may develop months or years after the onset of MAFH but may be present at the time of diagnosis. In this paper, we present a case of MAFH with co-existing peripheral T-cell lymphoma, in a 59 year-old man who died from disseminated disease. This adds another to the list of five such cases recorded in the literature since the recognition of MAFH (AU)