Cervical intraepithelial neoplasia is not associated with elevated serum neopterin levels
Cancer Epidemiol Biomarkers Prev
; 4(3): 295-8, Apr.-May 1995.
Article
em En
| MedCarib
| ID: med-12300
Biblioteca responsável:
JM3.1
Localização: JM3.1; Reprint collection
ABSTRACT
Neopterin, a marker of cellular immune activation, was elevated in patients who had cervical cancer in previous studies. To examine neopterin in the presence of precursors to cervical cancer (i.e. cervical intraepithelial) we measured serum levels in 185 colposcopy patients in Jamaica, a country with high cervical cancer incidence, and in 72 age-matched Jamaican women selected from a large population-based sample. We also measured serum levels of B-2 microglobulin, another commonly used marker of immune activation. Neopterin and B-2 microglobulin levels were not elevated in colposcopy patients; neither were they rel ted to severity of cervical neoplasia. In multivariable analysis, neither adjustments for detection of cervical human papillomavirus DNA by PCR nor detection of antibodies to human T-cell lymphotropic virus type 1 (a retrovirus endemic to Jamaica) altered our findings. The absence of serologically detectable increase in cellular immune activation linked to cervical intraepithelial neoplasmia does not involve susbtantial systemic immune activation. (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Biopterinas
/
Carcinoma in Situ
/
Biomarcadores Tumorais
/
Neoplasias do Colo do Útero
Tipo de estudo:
Risk_factors_studies
Limite:
Female
/
Humans
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
Cancer Epidemiol Biomarkers Prev
Ano de publicação:
1995
Tipo de documento:
Article