Epidemiology of human T-cell leukemia/lymphoma virus type 1 (HTLV-I) infections in a subpopulation of Afro-Caribbean origin in England
J Med Virol
; 29(4): 289-95, Dec. 1989.
Article
em En
| MedCarib
| ID: med-12368
Biblioteca responsável:
JM3.1
Localização: JM3.1; Reprint Collection
ABSTRACT
Epidemiological studies on neurological diseases in residents of Afro-Caribbean origin in the West Midlands region of England have identified eight patients with tropical spastic paraparesis (TSP), all of whom were found to be infected with human T-cell leukemia/lymphoma virus type 1 (HTLV-1). The husband of one of the patients with TSP was also infected with HTLV-1 and had a T-cell lymphoma. In addition, six asymptomatic HTLV-1-infected first-degree relatives of the TSP patients have been found. By anonymous testing of over 700 sera obtained from individuals of Afro-Caribbean, African, or Asian ethnic origin, seven HTLV-1-infected individuals were detected, who were all immigrants from the Caribbean. Overall, these numbers yielded a seroprevalence of HTLV-1 infections of 3.4 percent among the immigrant population of Afro-Caribbean origin, which is comparable with the prevalence of HTLV-1 in Jamaica in an equivalent age and sex cohort. Sera were tested for HTLV-1 antibody by means of three different procedures passive particle agglutination test (Serodia), indirect enzyme-labeled immunosorbent assay (ELISA; Dupont), and indirect immunoflourescence test (in-house, using HTLV-1-infected MT2 cells). The results of all three tests correlated very well with each other. HTLV-1 antibody titres in TSP patients were on the whole significantly higher than those of asymptomatic carriers, but some of the apparently healthy first-degree relatives and one anonymously tested individual had titres as high as most of the TSP patients. (AU)
Buscar no Google
Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Infecções por HTLV-I
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
Limite:
Aged
/
Female
/
Humans
/
Male
País/Região como assunto:
Caribe ingles
/
Europa
/
Jamaica
Idioma:
En
Revista:
J Med Virol
Ano de publicação:
1989
Tipo de documento:
Article