Neuroprotection by caffeine and pentoxifylline during experimental cerebral ischaemia
West Indian med. j
; 48(1): 23-5, Mar. 1999.
Artigo
em Inglês
| MedCarib
| ID: med-1240
Biblioteca responsável:
JM3.1
Localização: JM3.1; R18.W4
ABSTRACT
Cerebral ischaemia was induced in anaesthetized rats by occlusion of the ipsilateral common carotid and middle cerebral arteries. The response to ischaemia was assessed by the reduction of the amplitude of recorded somatosensory evoked potentials (SSEPs), and the rate of recovery of the SSEPs during reperfusion. Caffeine and pentoxifylline when applied at 70 mM to the cortex for 60 min prior to induction of ischaemia significantly reduced the ischaemia induced attenuation of the SSEPs and hastened recovery to control levels. In contrast, application of normal saline or of the drugs for 15 min did not reduce the effect of ischaemia on the SSEPs. These results suggest that caffeine and pentoxifylline have potential roles in the management of patients with cerebral ischaemia.(AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Pentoxifilina
/
Vasodilatadores
/
Cafeína
/
Isquemia Encefálica
/
Fármacos Neuroprotetores
/
Estimulantes do Sistema Nervoso Central
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
West Indian med. j
Ano de publicação:
1999
Tipo de documento:
Artigo