Glutamine production rate and its contribution to urinary ammonia in normal man
Clin Sci
; 62(3): 299-305, Mar. 1982.
Artigo
em Inglês
| MedCarib
| ID: med-12607
Biblioteca responsável:
JM3.1
Localização: JM3.1; R31.C56
ABSTRACT
Glutamine [15N]amide was infused at a steady rate of 33.34 micromoles/h into seven male adult volunteers who were in the fed state and normal acid-base status. Plasma glutamine amide N enrichment and urinary ammonia N enrichment rose to a constant value within 3h. The glutamine production rate was 51.8 ñ 7.9 millimoles/h. The total ammonia execretion rate was 0.87 millimoles/h. Of this excreted ammonia 62.6 ñ 9 percent was derived from the amide N atom of glutamine. The excreted glutamine amide N (0.53 millimoles/h) was only 1 percent of the glutamine production. If half the ammonia formed by the kidney is excreted in urine and half liberated into the renal vein in subjects with normal acid-base status [E. E. Owen & R. R. Robinson (1963) Journal of Clinical Investigation, 42, 263-276], then the kidney accounts for only 2 percent of glutamine disposal. Whole body protein turnover, measured from the urinary [15N]ammonia enrichment, was 30.3 ñ 7.7 g of N/day (2.8 g of protein/day/kg). (AU)
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Glutamina
/
Amônia
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clin Sci
Ano de publicação:
1982
Tipo de documento:
Artigo