Coagulation changes during the steady state in homozygous sickle-cell disease in Jamaica
Br J Haematol
; 30(2): 159-66, June 1975.
Article
em En
| MedCarib
| ID: med-12994
Biblioteca responsável:
JM3.1
Localização: JM3.1; RB145.A1B7
ABSTRACT
Coagulation studies were carried out in 117 Jamaicans with homozygous sickle-cell disease in the steady state, and 40 local controls. The patients had significantly higher factor-VIII levels, higher platelet counts, lower factor-V and plasminogen levels, shorter thrombin times and higher serum fibrinogen degradation products(FDP) than the control group. The low factor-V and plasminogen levels, and high FDP levels, might be explained by activation of the coagulation system and continuous clot lysis even in the absence of painful crisis. The high factor-VIII levels and short thrombin times found in these patients could not be explained.(Summary)
Buscar no Google
Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Coagulação Sanguínea
/
Anemia Falciforme
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
Br J Haematol
Ano de publicação:
1975
Tipo de documento:
Article