Studies in healthy human T-cell-leukemia lymphoma virus (HTLV-I) carriers from the Caribbean
Int J Cancer
; 38(1): 41-5, July 1986.
Article
em En
| MedCarib
| ID: med-13285
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC261.A34
ABSTRACT
Six healthy relatives of 3 adult T-cell leukemia lymphoma (ATLL) patients and 6 members of a Caribbean family immigrant to the UK have been investigated for the presence of HTLV-I and expression of interleukin 2(IL-2) receptors. Serum antibodies to HTLV-I were detected in all but 4 samples. Four to 10 percent of circulating cells from 3/4 seropositive donors studied displayed IL-2 receptors (anti-Tac+) and were shown to be convoluted lymphocytes by light microscopy morphology and immunoelectromicroscopy. After 5 to 28 days in culture, cells from 4 seropositive donors reacted with monoclonal antibodies (MAbs) against the HTLV-I core proteins, p19 and p24, and released retrovirus particles. Simmilar experiments with blood from 3 seronegative donors from the same families and 4 normal controls proved negative. Our findings indicate that seropositive individuals harbour the virus in a population of T-lymphocytes which may then acquire receptors for IL-2. These individuals are at risk of developing ATLL. (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Leucemia
/
Portador Sadio
/
Infecções por Retroviridae
Limite:
Humans
País/Região como assunto:
Caribe
/
Europa
Idioma:
En
Revista:
Int J Cancer
Ano de publicação:
1986
Tipo de documento:
Article