Rabies serum neutralizing antibody in mongooses from Grenada
Trans R Soc Trop Med Hyg
; 75(5): 654-66, 1981.
Artigo
em Inglês
| MedCarib
| ID: med-14419
Biblioteca responsável:
JM3.1
Localização: JM3.1; RC960.R6
ABSTRACT
During a four year study on Grenada, 4,754 mongooses were examined, of which 100 (2.1 percent) were rabid. Of 1,675 mongooses tested for rabies serum neutraslizing (SN) antibody, 498 (30 percent) were positive. During these four years (1971-74) the antibody prevalence rate increased from 20.8 percent to 43.3 percent, whereas the number of rabid mongooses decreased from 3.5 percent to 0.6 percent. Naturally acquired antibody was monitored in 20 captive mongooses for up to 35 months, and it was still circulating in 18 when monitoring ceased. The highest titre recorded was 11,400, and the rate of fall was highest in mongooses with high initial titres. High titres of naturally occuring antibody suggest recent rabies activity. 14 mongooses vaccinated parenterally with 1.0 ml of attenuated ERA vaccine showed substantial increases in antibody titres; most had titres greater than 11,000 one month later and maintained a high titre for several months. The highest recorded was 134,800. The virus titres of brain material from rabid mongooses ranged from 10 to the power 1.8 to 10 to the power 4.3 and, in some cases, were only slightly lower than those of salivary gland tissue (range 10 to the power 1 to 10 to the power 5.6) (Summary)
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Zoonoses
Base de dados:
MedCarib
Assunto principal:
Vírus da Raiva
/
Carnívoros
/
Herpestidae
/
Anticorpos Antivirais
Tipo de estudo:
Fatores de risco
País/Região como assunto:
Caribe
/
Caribe Inglês
/
Granada
Idioma:
Inglês
Revista:
Trans R Soc Trop Med Hyg
Ano de publicação:
1981
Tipo de documento:
Artigo