Some effects of metabolic acidosis on carbohydrate metabolism in the rat
Clin Sci
; 39(3): 375-82, Sept. 1970.
Article
em En
| MedCarib
| ID: med-14569
Biblioteca responsável:
JM3.1
Localização: JM3.1; R31.C56 / BB9.1
ABSTRACT
Metabolic acidosis was induced by feeding ammonium chloride to rats which were maintained on a carbohydrate diet for 48h. Fasting blood glucose was the same in acidotic and control animals, but there was an increase in liver glycogen in the former. Muscle glucogen was unchanged. In vitro glycogenesis was the same in liver slices from normal rats when incubated at a range of pH from 6.90 to 7.40. The peak blood glucose in response to intraperitoneal injections of glucagon was the same in control and acidotic rats. The rate of disappearence of glucose was slower in acidotic rats both after the glucagon induced hyperglycaemia and after intravenously injected glucose. Liver phosphorylase, total glycogen synthetase and the I form of this enzyme were unchanged in acidosis. The data are compatible with the hypothesis that in the acidotic rat there is a block in glycolysis-possibly at the phosphofructokinase step (Summary)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Acidose
/
Carboidratos
Limite:
Animals
Idioma:
En
Revista:
Clin Sci
Ano de publicação:
1970
Tipo de documento:
Article