Safety and immunogenicity of a new Haemophilus influenzae type b vaccine in infants under one year of age
Lancet
; 2(8249): 705-9, Oct. 1981.
Artigo
em Inglês
| MedCarib
| ID: med-14597
Biblioteca responsável:
JM3.1
Localização: JM3.1; R31.B7
ABSTRACT
64 healthy infants, 2-3 months old, were randomly assigned to one of three vaccination groups which either diphtheria-pertussis-tetanus (DPT) vaccine, Haemophilus influenzae type b capsular polysaccharide polyribosyl-ribitol phosphate (PRP) vaccine, or PRP+P (with pertussis adjuvant) vaccine in three doses at intervals of two months. Local and systemic reactions occurred most frequently after DPT vaccination and least frequently for PRP alone. Data for 60 infants from whom complete sera sets were available indicated that 70 percent of the infants who received three doses of PRP+P showed two fold or greater increases in titers of antibody to PRP with final values above the level assumed to give protection against invasive H. influenzae type b disease (>0.15 ug/ml). In contrast, less than 10 percent of infants who received PRP vaccine alone showed 2-fold or greater increases (Summary)
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
Doenças Negligenciadas
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Zoonoses
/
Meningite
Base de dados:
MedCarib
Assunto principal:
Haemophilus influenzae
/
Vacinação
Limite:
Humanos
/
Lactente
Idioma:
Inglês
Revista:
Lancet
Ano de publicação:
1981
Tipo de documento:
Artigo