Regulation of renal cortex ammoniagenesis. I. Stimulation of renal cortex ammoniagenesis in vitro by plasma isolated from acutely acidotic rats
J Clin Invest
; 53(1): 117-21, Jan. 1974.
Article
em En
| MedCarib
| ID: med-14819
Biblioteca responsável:
JM3.1
Localização: JM3.1; R11.J67
ABSTRACT
We studied the acute renal metabolic response in rats made acidotic by a single oral dose of ammonium chloride. Cortical slices from acutely (2-h) acidotic rats utilized more glutamine and produced more ammonia and glucose from glutamine than slices from normal animals. When cortical slices from normal rats were pretreated in vitro with plasma isolated from acutely acidotic rats, they achieved similar increases in glutamine utilization, ammonia formation, and gluconeogensis from glutamine. We did not observe such stimulation in normal cortical slices pretreated in a low pH-low bicarbonate medium. Our data show that a non-dialysable factor is present plasma from acutely acidotic rats that may be responsible for the early increase in the urinary ammonia observed in such animals (AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Amônia
/
Córtex Renal
Limite:
Animals
Idioma:
En
Revista:
J Clin Invest
Ano de publicação:
1974
Tipo de documento:
Article