Antidiarrhoeal effects of Ocimum gratissimum leaf extract in experimental animals
Journal of ethnopharmacology
; 68(1-3): 327-330, Dec. 15 1999. tab
Artigo
em Inglês
| MedCarib
| ID: med-17599
Biblioteca responsável:
TT5
Localização: TT5; W1, JO644CH
ABSTRACT
The aqueous extract of the leaves of Ocimum gratissimum was screened for antidiarrhoeal effects. The extract inhibited castor oil-induced diarrhoea in rats as judged by a decrease in the number of wet faeces in the extract-treated rats. In addition, the extract inhibited the propulsive movement of intestinal contents. On the isolated ileum of guinea-pig, the extract showed no direct action; however, it reduced the responses of the guinea-pig ileum to acetylcholine, nicotine and histamine. Phytochemical tests revealed the main constituents as tannins, steroids, triterpenoid and carbohydrates. These findings suggested that the aqueous extract of the leaves of O. gratissimum might elicit an antidiarrhoeal effect by inhibiting intestinal motility, partly via muscarinic receptor inhibition.
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Coleções:
Bases de dados internacionais
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
MedCarib
Assunto principal:
Trinidad e Tobago
/
Ocimum
/
Diarreia
/
Nigéria
Limite:
Animais
País/Região como assunto:
África
/
Caribe Inglês
/
Trinidad e Tobago
Idioma:
Inglês
Revista:
Journal of ethnopharmacology
Ano de publicação:
1999
Tipo de documento:
Artigo
Instituição/País de afiliação:
The University of the West Indies/Trinidad and Tobago
/
University of Nigeria/Nigeria