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Insulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects
Ezenwaka, C. E. ; Nwagbara, E. ; Seales, D. ; Okali, F. ; Sell, H. ; Eckel, J. .
Afiliação
  • Ezenwaka, C. E. ; The University of the West Indies. Faculty of Medical Sciences. Pathology and Microbiology Unit. St. Augustine. Trinidad and Tobago
  • Nwagbara, E. ; Tobago Regional Health Authority. Scarborough. Trinidad and Tobago
  • Seales, D. ; The University of the West Indies. Faculty of Medical Sciences. Pathology and Microbiology Unit. St. Augustine. Trinidad and Tobago
  • Okali, F. ; Tobago Regional Health Authority. Scarborough. Trinidad and Tobago
  • Sell, H. ; German Diabetes Center. Institute of Clinical Biochemistry and Pathobiochemistry. Dsseldorf. Germany
  • Eckel, J. ; German Diabetes Center. Institute of Clinical Biochemistry and Pathobiochemistry. Dsseldorf. Germany
Archives of physiology and biochemistry ; 115(1): 22-27, Feb. 2009. tab
Article em En | MedCarib | ID: med-17686
Biblioteca responsável: TT5
ABSTRACT

AIM:

To determine how the levels of leptin and monocyte chemotactic protein-1 (MCP-1) are associated with insulin resistance (IR) in obese, non-obese, diabetic and non-diabetic subjects.

METHODS:

112 type 2 diabetics and 43 non-diabetics were studied fasting. Anthropometric indices were measured and glucose, insulin, leptin and MCP-1 were measured in blood. IR was calculated.

RESULTS:

MCP-1 level was significantly higher in diabetics than non-diabetics irrespective of gender (p < 0.05). Irrespective of diabetes status, the serum leptin concentration was significantly higher (p < 0.05) in obese and females subjects than in non-obese and male subjects respectively. There were no significant correlations between IR and MCP-1 or leptin in all subgroups of subjects studied. General linear modelling analysis showed that only diabetes state significantly predicted MCP-1 levels (p < 0.05) whereas non of the factors predicted leptin levels (p > 0.05).

CONCLUSION:

Routine measurement of leptin and MCP-1 would be potentially useful in assessment of patients for the metabolic syndrome or coronary heart disease especially in black population.
Assuntos
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Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Resistência à Insulina / Quimiocina CCL2 / Doença das Coronárias / Síndrome Metabólica / Diabetes Mellitus Tipo 2 / Obesidade Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Archives of physiology and biochemistry Ano de publicação: 2009 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MedCarib Assunto principal: Resistência à Insulina / Quimiocina CCL2 / Doença das Coronárias / Síndrome Metabólica / Diabetes Mellitus Tipo 2 / Obesidade Tipo de estudo: Prognostic_studies Limite: Female / Humans / Male Idioma: En Revista: Archives of physiology and biochemistry Ano de publicação: 2009 Tipo de documento: Article