Insulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects
Archives of physiology and biochemistry
; 115(1): 22-27, Feb. 2009. tab
Article
em En
| MedCarib
| ID: med-17686
Biblioteca responsável:
TT5
ABSTRACT
AIM:
To determine how the levels of leptin and monocyte chemotactic protein-1 (MCP-1) are associated with insulin resistance (IR) in obese, non-obese, diabetic and non-diabetic subjects.METHODS:
112 type 2 diabetics and 43 non-diabetics were studied fasting. Anthropometric indices were measured and glucose, insulin, leptin and MCP-1 were measured in blood. IR was calculated.RESULTS:
MCP-1 level was significantly higher in diabetics than non-diabetics irrespective of gender (p < 0.05). Irrespective of diabetes status, the serum leptin concentration was significantly higher (p < 0.05) in obese and females subjects than in non-obese and male subjects respectively. There were no significant correlations between IR and MCP-1 or leptin in all subgroups of subjects studied. General linear modelling analysis showed that only diabetes state significantly predicted MCP-1 levels (p < 0.05) whereas non of the factors predicted leptin levels (p > 0.05).CONCLUSION:
Routine measurement of leptin and MCP-1 would be potentially useful in assessment of patients for the metabolic syndrome or coronary heart disease especially in black population.
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Resistência à Insulina
/
Quimiocina CCL2
/
Doença das Coronárias
/
Síndrome Metabólica
/
Diabetes Mellitus Tipo 2
/
Obesidade
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Archives of physiology and biochemistry
Ano de publicação:
2009
Tipo de documento:
Article