Anaemia and kidney dysfunction in Caribbean type 2 diabetic patients.
Cardiovascular diabetology
; 7(25)Aug 2008. tab
Artigo
em Inglês
| MedCarib
| ID: med-17728
Biblioteca responsável:
TT5
ABSTRACT
BACKGROUND:
Anaemia has been shown in previous studies to be a risk factor for cardiovascular disease in diabetic patients with chronic kidney disorder. This study was aimed to assess the prevalence of anaemia and kidney dysfunction in Caribbean type 2 diabetic patients that have been previously shown to have a high prevalence of the metabolic syndrome.METHODS:
155 type 2 diabetic patients and 51 non-diabetic subjects of African origin were studied. Anthropometric parameters were measured and fasting blood samples were collected for glucose, creatinine, glycated hemoglobin and complete blood count. Anaemia was defined as haemoglobin < 12 g/dl (F) or < 13 g/dl (M). Kidney function was assessed using glomerular filtration rate (GFR) as estimated by the four-variable Modification of Diet in Renal Disease (MDRD) study equation. Subjects were considered to have chronic kidney disease when the estimated GFR was < 60 ml/min per 1.73 m2. Comparisons for within- and between-gender, between diabetic and non-diabetic subjects were performed using Student's t-test while chi-square test was employed for categorical variables.RESULTS:
The diabetic patients were older than the non-diabetic subjects. While male non-diabetic subjects had significantly higher red blood cell count (RBC), haemoglobin and hematocrit concentrations than non-diabetic female subjects (p < 0.001), the RBC and hematocrit concentrations were similar in male and female diabetic patients. Furthermore, irrespective of gender, diabetic patients had significantly higher prevalence rate of anemia than non-diabetic subjects (p < 0.05). Anaemic diabetes patients had significantly lower GFR (67.1 +/- 3.0 vs. 87.9 +/- 5.4 ml/min per 1.73 m2, p < 0.001) than non-anaemic patients.CONCLUSION:
A high prevalence of anaemia was identified in this group of type 2 diabetic patients previously shown to have a high prevalence of the metabolic syndrome.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Trinidad e Tobago
/
Índias Ocidentais
/
Diabetes Mellitus Tipo 2
/
Anemia
/
Rim
Tipo de estudo:
Estudo prognóstico
/
Fatores de risco
Limite:
Humanos
País/Região como assunto:
Caribe
/
Caribe Inglês
/
Trinidad e Tobago
Idioma:
Inglês
Revista:
Cardiovascular diabetology
Ano de publicação:
2008
Tipo de documento:
Artigo
Instituição/País de afiliação:
Tobago Regional Health Authority/Trinidad and Tobago
/
University of the West Indies/Trinidad and Tobago