Slipped-strand mispairing at noncontiguous repeats in Poecilia reticulata: a model for minisatellite birth
Genetics
; 155(3): 1313-1320, Jul. 2000. tab, graf
Artigo
em Inglês
| MedCarib
| ID: med-17772
Biblioteca responsável:
TT5
ABSTRACT
The standard slipped-strand mispairing (SSM) model for the formation of variable number tandem repeats (VNTRs) proposes that a few tandem repeats, produced by chance mutations, provide the "raw material" for VNTR expansion. However, this model is unlikely to explain the formation of VNTRs with long motifs (e.g., minisatellites), because the likelihood of a tandem repeat forming by chance decreases rapidly as the length of the repeat motif increases. Phylogenetic reconstruction of the birth of a mitochondrial (mt) DNA minisatellite in guppies suggests that VNTRs with long motifs can form as a consequence of SSM at noncontiguous repeats. VNTRs formed in this manner have motifs longer than the noncontiguous repeat originally formed by chance and are flanked by one unit of the original, noncontiguous repeat. SSM at noncontiguous repeats can therefore explain the birth of VNTRs with long motifs and the "imperfect" or "short direct" repeats frequently observed adjacent to both mtDNA and nuclear VNTRs.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
DNA Mitocondrial
/
Sequência de Bases
/
Repetições Minissatélites
/
Pareamento Incorreto de Bases
/
Genética Populacional
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
País/Região como assunto:
Caribe Inglês
/
Trinidad e Tobago
Idioma:
Inglês
Revista:
Genetics
Ano de publicação:
2000
Tipo de documento:
Artigo
Instituição/País de afiliação:
Simon Fraser University/Canada