Grey matter abnormalities in first-episode schizophrenia and affective psychosis.
The British journal of psychiatry
; 191(supl. 51): s111-s116, Dec. 2007. tab
Artigo
em Inglês
| MedCarib
| ID: med-17797
Biblioteca responsável:
TT5
Localização: TT5; W1, BR616
ABSTRACT
BACKGROUND:
Grey matter and other structural brain abnormalities are consistently reported in first-onset schizophrenia, but less is known about the extent of neuroanatomical changes in first-onset affective psychosis.AIMS:
To determine which brain abnormalities are specific to (a) schizophrenia and (b) affective psychosis.METHOD:
We obtained dual-echo (proton density/T2-weighted) magnetic resonance images and carried out voxel-based analysis on the images of 73 patients with first-episode psychosis (schizophrenia n=44, affective psychosis n=29) and 58 healthy controls.RESULTS:
Both patients with schizophrenia and patients with affective psychosis had enlarged lateral and third ventricle volumes. Regional cortical grey matter reductions (including bilateral anterior cingulate gyrus, left insula and left fusiform gyrus) were evident in affective psychosis but not in schizophrenia, although patients with schizophrenia displayed decreased hippocampal grey matter and increased striatal grey matter at a more liberal statistical threshold.CONCLUSIONS:
Both schizophrenia and affective psychosis are associated with volumetric abnormalities at the onset of frank psychosis, with some of these evident in common brain areas.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Transtornos Psicóticos
/
Esquizofrenia
/
Anormalidades Congênitas
/
Trinidad e Tobago
Tipo de estudo:
Estudo prognóstico
Limite:
Humanos
País/Região como assunto:
Caribe Inglês
/
Trinidad e Tobago
Idioma:
Inglês
Revista:
The British journal of psychiatry
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
Department of Neurology/United Kingdom
/
Department of Psychiatry/Australia
/
Department of Psychiatry/Trinidad and Tobago
/
Department of Psychiatry/United Kingdom
/
Department of Psychology/United Kingdom
/
Division of Psychological Medicine/United Kingdom
/
Fulbourn Hospital/United Kingdom