Effect of alloxan diabetes, on glicentin-secreting L-cells in the small intestine of Sprague Dawley rats,
West Indian Veterinary Journal
; 5(1): 19-22, November 2005. ilus
Artigo
em Inglês
| MedCarib
| ID: med-17844
Biblioteca responsável:
TT5
Localização: TT5; W1, JO91517
ABSTRACT
The L-cells of the small intestine synthesize a proglucagon molecule which is processed to form glicentin, oxyntomodulin, glucagon-like peptide 1 (GLP-1) and glucagons-like peptide 2 (GLP-2). Glicentin and oxyntomodulin inhibit gastric secretion, and delay tansit time through the stomach. Serum concentrations of GLP-1 and GLP-2 have been reported to vary in types 1 and 2 diabetes and in streptozocin induced diabetic rats. It was initially thought that these variations were due to the activity of intestinal L- cells, but it was later found that this was from pancreatic alpha cells. Very little work had been done on the effect of diabetes on glicentin producing cells of the gut. In this experiment the effects of alloxan diabetes on glicentin producing L-cells of the intestines was investigated using immunohistochemical techniques. Results showed that the immunoreactivity of glicentin was noticeablly reduced in the L-cells of the small intestine of alloxan-diabetic rats.
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Coleções:
Bases de dados internacionais
Base de dados:
MedCarib
Assunto principal:
Diabetes Mellitus Experimental
Limite:
Animais
Idioma:
Inglês
Revista:
West Indian Veterinary Journal
Ano de publicação:
2005
Tipo de documento:
Artigo
Instituição/País de afiliação:
The University of the West Indies/Trinidad and Tobago