Microalbuminuria, renal function and waist: hip ratio in black hypertensive Jamaicans
J Hum Hypertens
; 12(4): 221-7, Apr. 1998.
Article
em En
| MedCarib
| ID: med-1790
Biblioteca responsável:
JM3.1
Localização: JM3.1; Reprint Collection
ABSTRACT
OBJECTIVE:
To investigate the relationship between blood pressure (BP), renal haemodynamics, anthropometric measures of obesity and urinary albumin excretion in hypertension and in a control group.METHODS:
Urinary albumin, BP and anthropometric measurements were carried out in patients attending hypertension clinic of the University Hospital of the West Indies. A randomised stratified sample was then selected for renal haemodynamic assessment. A normoalbuminuric control group without hypertension or diabetes was also selected. Renal haemodynamics was assess by measured glomerular filtration rate using 51-chromium edetic acid (51 Cr-EDTA) and renal blood flow using 125-iodohippurate (125-PAH).RESULTS:
Urinary albumium excretion was postively and significantly correlated with systolic pressure (B = 0.011, P < 0.003, R = 0.22), current body weight (B = 0.014, P < 0.04, R = 0.15) and the pressure of diabetes (B = 0.9, P < 0.001, R = 0.3). In the sample selected for renal haemodynamics, patients with microalbuminuria had lower age-adjusted corrected renal blood flow (P < 0.006), effective renal plasma flow (P < 0.006) when compared with patients without microalbuminuria was not different from those without. Urinary albumin excretion was postively and significantly correlated with systolic pressure (B = 0.016, P < 0.003, R = 0.40) and inversely related to corrected renal flow (B = -1.13, P < 0.0002, R = 0.46) Waist hip ratio was inversely related to corrected renal blood flow (B = -1.74, P < 0.02, adjusted R = 0.48).CONCLUSION:
Systolic BP, diabetes and body weight were significant predictors of albuminuria in our patients. Microalbuminuria and body fat distribution as assessed by waist hip ratio were important determinants of renal haemodynamics in this population.(AU)
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Coleções:
01-internacional
Base de dados:
MedCarib
Assunto principal:
Constituição Corporal
/
Albuminúria
/
Hipertensão
/
Rim
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Male
País/Região como assunto:
Caribe ingles
/
Jamaica
Idioma:
En
Revista:
J Hum Hypertens
Ano de publicação:
1998
Tipo de documento:
Article